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Cholesterol and steroid metabolism enzymes
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Cholesterol and steroid metabolism enzymes
v
t
e
Metabolism
:
lipid metabolism
–
ketones
/
cholesterol
synthesis
enzymes
/
steroid metabolism
Mevalonate pathway
To
HMG-CoA
Acetyl-Coenzyme A acetyltransferase
HMG-CoA synthase
(regulated step)
Ketogenesis
HMG-CoA lyase
3-hydroxybutyrate dehydrogenase
Thiophorase
To
Mevalonic acid
HMG-CoA reductase
To
DMAPP
Mevalonate kinase
Phosphomevalonate kinase
Pyrophosphomevalonate decarboxylase
Isopentenyl-diphosphate delta isomerase
Geranyl-
Dimethylallyltranstransferase
Geranyl pyrophosphate
To
cholesterol
To
lanosterol
Farnesyl-diphosphate farnesyltransferase
Squalene monooxygenase
Lanosterol synthase
7-Dehydrocholesterol
path
Lanosterol 14α-demethylase
Sterol-C5-desaturase-like
7-Dehydrocholesterol reductase
Desmosterol
path
24-Dehydrocholesterol reductase
To
Bile acids
Cholesterol 7α-hydroxylase
Sterol 27-hydroxylase
Steroidogenesis
To
pregnenolone
Cholesterol side-chain cleavage
To
corticosteroids
aldosterone
:
18-Hydroxylase
cortisol
/
cortisone
:
17α-Hydroxylase
[[11β-Hydroxysteroid dehydrogenase|11β-
HSD
]]
1
2
both:
[[3β-Hydroxysteroid dehydrogenase|3β-
HSD
]]
1
2
21-Hydroxylase
11β-Hydroxylase
To
sex hormones
To
androgens
17α-Hydroxylase
17,20-Lyase
[[3β-Hydroxysteroid dehydrogenase|3β-
HSD
]]
[[17β-Hydroxysteroid dehydrogenase|17β-
HSD
]]
5α-Reductase
1
2
To
estrogens
Aromatase
[[17β-Hydroxysteroid dehydrogenase|17β-
HSD
]]
Other/ungrouped
Steroid metabolism
:
sulfatase
Steroid sulfatase
sulfotransferase
SULT1A1
SULT2A1
Steroidogenic acute regulatory protein
Cholesterol total synthesis
Reverse cholesterol transport
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